Maria Mihaylova, PhD

Primary Research Questions addressed by Dr. Mihaylova's Lab

The goal of our work is to understand how metabolic deregulation can predispose to or accelerate age-associated diseases, including cancer. In particular, we are interested in understanding the molecular mechanisms of nutrient sensing and nutrient utilization in the intestine and liver and determining how these processes are influenced by diet, age, and the microbiota. To get at these questions, we employ several genetic and multidisciplinary analytical approaches, both in mouse models and in 3D organoid culture systems. Our ultimate goal is to translate our findings into potential therapeutics for metabolic diseases and cancer.

Areas of Expertise

• Biochemistry
• Cancer
• Metabolomics
• Nutrition (biomedical and molecular)

Primary Research Tools and Methods

• Animal Studies
• Cell Culture
• Single Cell Analysis